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National Journal of Maxillofacial Surgery
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Year : 2020  |  Volume : 11  |  Issue : 2  |  Page : 241-247

Comparative evaluation of bone regeneration with platelet-rich fibrin in mandibular third molar extraction socket: A randomized split-mouth study

1 Department of Oral and Maxillofacial Surgery, MM College of Dental Sciences and Research, MM (Deemed to be University), Ambala, Haryana, India
2 Department of Conservative Dentistry and Endodontics, MM College of Dental Sciences and Research, MM (Deemed to be University), Ambala, Haryana, India

Correspondence Address:
Dr. Atul Sharma
296, Old Housing Board, Sector-13, Karnal, Haryana
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/njms.NJMS_50_19

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Purpose: Platelet-rich fibrin (PRF) is a new platelet concentrate concept consisting of an autologous fibrin gel having accumulation of platelets and the released cytokines in a fibrin clot. The study aims to evaluate the efficacy of autologous PRF in accelerating bone regeneration and repair in fresh third molar extraction sockets. The investigators hypothesized the cicatricial properties and accumulation of growth factors in a single clot which will improve bone density and quality. Materials and Methods: PRF results from a natural and progressive polymerization occurring during centrifugation. Two groups were made with bilaterally impacted third molar patients. PRF was obtained and surgical extraction was carried out under aseptic conditions. Quantitative data are presented as mean. Statistical significance was inferred at P < 0.05. Results: Results obtained were evaluated statistically and found a significant difference between the groups in improvement in alveolar bone density of regenerate measured radiographically. The study demonstrates a faster bone formation in the extracted sockets with PRF as compared to control. Conclusion: PRF proved to be an autologous biomaterial with useful features that allowed efficient postextraction bone defect filling and faster bone regeneration.

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