|LETTER TO EDITOR
|Year : 2014 | Volume
| Issue : 2 | Page : 247
Mitochondrial C-tract and tobacco exposure in oral precancer cases
Sim Sai Tin1, Viroj Wiwanitkit2
1 Department of Medical Science, Medical Center, Shantou, China
2 Department of Tropical Medicine, Hainan Medical University, China
|Date of Web Publication||10-Apr-2015|
Sim Sai Tin
Department of Medical Science, Medical Center, Shantou
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Tin SS, Wiwanitkit V. Mitochondrial C-tract and tobacco exposure in oral precancer cases. Natl J Maxillofac Surg 2014;5:247
|How to cite this URL:|
Tin SS, Wiwanitkit V. Mitochondrial C-tract and tobacco exposure in oral precancer cases. Natl J Maxillofac Surg [serial online] 2014 [cited 2021 May 9];5:247. Available from: https://www.njms.in/text.asp?2014/5/2/247/154852
We would like to discuss about the article titled "Association between mitochondrial C-tract alteration and tobacco exposure in oral precancer cases" by Pandey et al.,  published in your journal. Pandey et al. had reported, "tobacco in both forms, chewable and smoke, is oncogenic and causes early changes in mitochondrial genome and the chances increase with increasing duration of tobacco consumption."  In fact, to evaluate the risk of cancer, there are several tools. Detection of mitochondrial C-tract alteration can be used as a tool. However, it should be mentioned that mitochondrial C-tract alteration only implies cytogenetic change and it does not relate to exposure. To trace the relationship, monitoring of the exposure level by a biomarker is needed. A good biomarker that can be used in the present case is cotinine. Finally, the risk can also be modified by other factors. Betel chewing  and HPV infection  are good examples of these factors. These factors have not been ruled out by Pandey et al. 
| References|| |
Pandey R, Mehrotra D, Mahdi AA, Sarin R, Kowtal P, Maurya SS, et al
. Association between mitochondrial C-tract alteration and tobacco exposure in oral precancer cases. Natl J Maxillofac Surg 2013;4:219-24.
Lee CH, Ko YC, Huang HL, Chao YY, Tsai CC, Shieh TY, et al
. The precancer risk of betel quid chewing, tobacco use and alcohol consumption in oral leukoplakia and oral submucous fibrosis in southern Taiwan. Br J Cancer 2003;88:366-72.
Mondal R, Ghosh SK, Choudhury JH, Seram A, Sinha K, Hussain M, et al
. Mitochondrial DNA copy number and risk of oral cancer: A report from Northeast India. PLoS One 2013;8:e57771.