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National Journal of Maxillofacial Surgery
 
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REVIEW ARTICLE
Year : 2011  |  Volume : 2  |  Issue : 1  |  Page : 15-16

Oral lichen planus - Review on etiopathogenesis


Department of Oral Medicine & Radiology, Career Postgraduate Institute of Dental Sciences & Hospital, Sitapur Road, Lucknow, India

Correspondence Address:
K Aravinda
Department of Oral Medicine & Radiology, Career Postgraduate Institute of Dental Sciences & Hospital, Sitapur Road, Lucknow - 226 020, Uttar Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0975-5950.85847

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Oral lichen planus (OLP) is a chronic mucocutaneous disease of uncertain etiopathogenesis. Several factors including stress, genetics, systemic diseases, viruses, dental restorative materials and drugs have been implicated as causative agents. The disease seems to be mediated by an antigen specific mechanism, activating cytotoxic T cells, and non specific mechanisms like mast cell degranulation and matrix metalloproteinase activation. Further clarity on the pathogenesis will aid in modifying therapeutic interventions, thus significantly reducing the morbidity of OLP patients.


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